Imaging and tissue biodistribution of 99mTc-labeled adenovirus knob (serotype 5)

@article{Zinn1998ImagingAT,
  title={Imaging and tissue biodistribution of 99mTc-labeled adenovirus knob (serotype 5)},
  author={K. Zinn and J Douglas and C Smyth and H-G Liu and Qingping Wu and V Krasnykh and J Mountz and D T Curiel},
  journal={Gene Therapy},
  year={1998},
  volume={5},
  pages={798-808}
}
Hepatic sequestration of systemically administered adenoviral vectors reduces the number of viral particles available for delivery to other tissues. The biological basis of this phenomenon was investigated using a new in vivo technique which permitted imaging in real time. Recombinant adenovirus serotype 5 knob (Ad5K) was radiolabeled with the gamma-emitter 99mTc (half-life = 6 h). Scatchard analysis of the 99mTc-Ad5K showed specific, high-affinity binding to U293 cells (Kd = 1.4 ± 0.5 nM… CONTINUE READING

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