Imaging and modeling of acute pressure-induced changes of collagen and elastin microarchitectures in pig and human resistance arteries.

@article{Bloksgaard2017ImagingAM,
  title={Imaging and modeling of acute pressure-induced changes of collagen and elastin microarchitectures in pig and human resistance arteries.},
  author={Maria Bloksgaard and Thomas M. Leurgans and Bart Spronck and Maarten H G Heusinkveld and Bjarne Thorsted and Kristoffer Rosenstand and Inger Nissen and Ulla M{\o}ller Hansen and Jonathan R. Brewer and Luis A. Bagatolli and Lars Melholt Rasmussen and Akhmadjon 6 Irmukhamedov and Koen D. Reesink and Jo G R De Mey},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2017},
  volume={313 1},
  pages={
          H164-H178
        }
}
The impact of disease-related changes in the extracellular matrix (ECM) on the mechanical properties of human resistance arteries largely remains to be established. Resistance arteries from both pig and human parietal pericardium (PRA) display a different ECM microarchitecture compared with frequently used rodent mesenteric arteries. We hypothesized that the biaxial mechanics of PRA mirror pressure-induced changes in the ECM microarchitecture. This was tested using isolated pig PRA as a model… CONTINUE READING
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