Imaging and analytical methods as applied to the evaluation of vasculature and hypoxia in human brain tumors.

@article{Evans2008ImagingAA,
  title={Imaging and analytical methods as applied to the evaluation of vasculature and hypoxia in human brain tumors.},
  author={Sydney M Evans and Kevin W. Jenkins and W. Timothy Jenkins and Thomas J. Dilling and Kevin D. Judy and Amy E Schrlau and Alexander R. Judkins and Stephen M. Hahn and Cameron J. Koch},
  journal={Radiation research},
  year={2008},
  volume={170 6},
  pages={677-90}
}
Tissue hypoxia results from the interaction of cellular respiration, vascular oxygen carrying capacity, and vessel distribution. We studied the relationship between tumor vasculature and regions of low pO(2) using quantitative analysis of binding of the 2-nitroimidazole EF5 given to patients intravenously (21 mg/kg) approximately 24 h preceding surgery. We describe new computer algorithms for determining EF5 binding as a function of radial distance from individual blood vessels and converting… CONTINUE READING

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