Imaging and CSF studies in the preclinical diagnosis of Alzheimer's disease.

  title={Imaging and CSF studies in the preclinical diagnosis of Alzheimer's disease.},
  author={Mony J de Leon and Lisa Mosconi and K Blennow and S Desanti and Ray Zinkowski and Pankaj D. Mehta and Domenico Pratic{\`o} and W Tsui and Leslie A Saint Louis and L Sobanska and Miroslaw Brys and Yan-sheng Li and Kenneth C. Rich and Juha Rinne and Henry Rusinek},
  journal={Annals of the New York Academy of Sciences},
It is widely believed that the path to early and effective treatment for Alzheimer's disease (AD) requires the development of early diagnostic markers that are both sensitive and specific. To this aim, using longitudinal study designs, we and others have examined magnetic resonance imaging (MRI), 2-fluoro-2-deoxy-d-glucose-positron emission tomography (FDG/PET), and cerebrospinal fluid (CSF) biomarkers in cognitively normal elderly (NL) subjects and in patients with mild cognitive impairment… CONTINUE READING


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