Imaging acetylcholinesterase density in peripheral organs in Parkinson's disease with 11C-donepezil PET.

@article{Gjerlff2015ImagingAD,
  title={Imaging acetylcholinesterase density in peripheral organs in Parkinson's disease with 11C-donepezil PET.},
  author={Trine Gjerl\off and Tatyana A. Fedorova and Karoline Knudsen and Ole Lajord Munk and Adjmal Nahimi and Steen Jacobsen and Erik H. Danielsen and Astrid Juhl Terkelsen and John Hansen and Nicola Pavese and David J. Brooks and Per Borghammer},
  journal={Brain : a journal of neurology},
  year={2015},
  volume={138 Pt 3},
  pages={653-63}
}
Parkinson's disease is associated with early parasympathetic dysfunction leading to constipation and gastroparesis. It has been suggested that pathological α-synuclein aggregations originate in the gut and ascend to the brainstem via the vagus. Our understanding of the pathogenesis and time course of parasympathetic denervation in Parkinson's disease is limited and would benefit from a validated imaging technique to visualize the integrity of parasympathetic function. The positron emission… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 32 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 54 references

In vivo imaging of human acetylcholinesterase density in peripheral organs using 11C-donepezil: dosimetry, biodistribution, and kinetic analyses

  • T Gjerløff, S Jacobsen, A Nahimi, OL Munk, D Bender, AK Alstrup
  • J Nucl Med
  • 2014
Highly Influential
19 Excerpts

Die Wirkung einer subtotalen Vagotomie auf den Plexus myentericus (Auerbach) verschiedener Darmabschnitte

  • W Schmid, E van der Zypen, H. Keller
  • Acta Anat (Basel)
  • 1979
Highly Influential
5 Excerpts

Similar Papers

Loading similar papers…