Imaging a functional tumorigenic biomarker in the transformed epithelium.


Proteases responsible for the increased peritumoral proteolysis associated with cancer represent functional biomarkers for monitoring tumorigenesis. One attractive extracellular biomarker is the transmembrane serine protease matriptase. Found on the surface of epithelial cells, the activity of matriptase is regulated by its cognate inhibitor hepatocyte… (More)
DOI: 10.1073/pnas.1218694110

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