Imaging Integrin αvβ3 on Blood Vessels with 111In-RGD2 in Head and Neck Tumor Xenografts

  title={Imaging Integrin $\alpha$v$\beta$3 on Blood Vessels with 111In-RGD2 in Head and Neck Tumor Xenografts},
  author={Samantha Y. A. Terry and K. R. Abiraj and Cathelijne Frielink and Laura K van Dijk and Johan Bussink and Wim J. G. Oyen and Otto C Boerman},
  journal={The Journal of Nuclear Medicine},
  pages={281 - 286}
Arginine-glycine-aspartic acid (RGD)–based imaging tracers allow specific imaging of integrin αvβ3, a protein overexpressed during angiogenesis, leading to the possibility that it might serve as a tool to stratify patients for antiangiogenic treatment. However, these tracers have generally been characterized in xenograft models in which integrin αvβ3 was constitutively expressed by the tumor cells themselves. In the studies presented here, the use of 111In-RGD2 as a tracer to image only… 

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