Imaging Glutamate Homeostasis in Cocaine Addiction with the Metabotropic Glutamate Receptor 5 Positron Emission Tomography Radiotracer [<ce:sup loc=pre>11</ce:sup>C]ABP688 and Magnetic Resonance Spectroscopy

@article{Martinez2014ImagingGH,
  title={Imaging Glutamate Homeostasis in Cocaine Addiction with the Metabotropic Glutamate Receptor 5 Positron Emission Tomography Radiotracer [<ce:sup loc=pre>11</ce:sup>C]ABP688 and Magnetic Resonance Spectroscopy},
  author={Diana Martinez and Mark Slifstein and Nabeel Nabulsi and Alexander Grassetti and Yiyun Huang},
  journal={Biological Psychiatry},
  year={2014},
  volume={75},
  pages={165-171}
}
BACKGROUND Preclinical studies demonstrate that glutamate homeostasis in the striatum is disrupted following cocaine exposure, including a decrease in metabotropic glutamate receptor type 5 (mGluR5) expression and reduced glutamate turnover. The goal of this study was to use imaging of the human brain to investigate alterations in the glutamate signaling in cocaine addiction. METHODS Positron emission tomography imaging with the radiotracer [(11)C]ABP688 was used to measure mGluR5 binding and… CONTINUE READING
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