Imaging Cortical Dynamics at High Spatial and Temporal Resolution with Novel Blue Voltage-Sensitive Dyes

@article{Shoham1999ImagingCD,
  title={Imaging Cortical Dynamics at High Spatial and Temporal Resolution with Novel Blue Voltage-Sensitive Dyes},
  author={Doron Shoham and D. E. Glaser and Amos Arieli and Tal Kenet and Chaipi Wijnbergen and Yuval Toledo and Rina Hildesheim and Amiram Grinvald},
  journal={Neuron},
  year={1999},
  volume={24},
  pages={791-802}
}
Conventional imaging techniques have provided high-resolution imaging either in the spatial domain or in the temporal domain. Optical imaging utilizing voltage-sensitive dyes has long had the unrealized potential to achieve high resolution in both domains simultaneously, providing subcolumnar spatial detail with millisecond precision. Here, we present a series of developments in voltage-sensitive dyes and instrumentation that make functional imaging of cortical dynamics practical, in both… CONTINUE READING
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