Imaging CXCL12-CXCR4 Signaling in Ovarian Cancer Therapy

Abstract

Chemokine CXCL12 and receptor CXCR4 have emerged as promising therapeutic targets for ovarian cancer, a disease that continues to have a dismal prognosis. CXCL12-CXCR4 signaling drives proliferation, survival, and invasion of ovarian cancer cells, leading to tumor growth and metastasis. Pleiotropic effects of CXCR4 in multiple key steps in ovarian cancer… (More)
DOI: 10.1371/journal.pone.0051500

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