Imaging β-amyloid using [18F]flutemetamol positron emission tomography: from dosimetry to clinical diagnosis
@article{Heurling2015ImagingU, title={Imaging $\beta$-amyloid using [18F]flutemetamol positron emission tomography: from dosimetry to clinical diagnosis}, author={Kerstin Heurling and Antoine Leuzy and Eduardo R. Zimmer and Mark Lubberink and Agneta Nordberg}, journal={European Journal of Nuclear Medicine and Molecular Imaging}, year={2015}, volume={43}, pages={362-373} }
In Alzheimer’s disease (AD), the deposition of β-amyloid (Aβ) is hypothesized to result in a series of secondary neurodegenerative processes, leading ultimately to synaptic dysfunction and neuronal loss. Since the advent of the first Aβ-specific positron emission tomography (PET) ligand, 11C-Pittsburgh compound B ([11C]PIB), several 18F ligands have been developed that circumvent the limitations of [11C]PIB tied to its short half-life. To date, three such compounds have been approved for…
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References
SHOWING 1-10 OF 93 REFERENCES
[18F]Flutemetamol amyloid-beta PET imaging compared with [11C]PIB across the spectrum of Alzheimer’s disease
- Medicine, BiologyEuropean Journal of Nuclear Medicine and Molecular Imaging
- 2013
[18F]FMM PET imaging detects Aβ deposition in patients along the continuum from normal cognitive status to dementia of AD and discriminates AD patients from HC subjects, similar to [11C]PIB PET.
Flutemetamol (18F): a β-amyloid positron emission tomography tracer for Alzheimer's and dementia diagnosis.
- Biology, MedicineDrugs of today
- 2014
Flutemetamol (18F) (Vizamyl™) is a novel (18)F-labeled radiotracer for positron emission tomography (PET) that is rapidly taken up into the brain and binds to β-amyloid deposits and can be reliably quantified by the use of relative standard uptake value ratios.
Flutemetamol (18F): a β-amyloid positron emission tomography tracer for Alzheimer's and dementia diagnosis.
- Biology, Medicine
- 2014
Flutemetamol (18F) (Vizamyl) is a novel 18F-labeled radiotracer for positron emission tomography (PET) that is rapidly taken up into the brain and binds to beta-amyloid deposits, leading to the agent's approval to assist in the assessment of amyloid plaque pathology in AD patients.
In vivo PET imaging of beta-amyloid deposition in mouse models of Alzheimer's disease with a high specific activity PET imaging agent [18F]flutemetamol
- Biology, MedicineEJNMMI Research
- 2014
The high specific activity of 18F-labelled amyloid imaging positron emission tomography (PET) agent [18F]flutemetamol did not provide a notable advantage in Tg2576 and APPswe-PS1dE9 mice compared to the previously evaluated structural analogue [11C].
Development of positron emission tomography β-amyloid plaque imaging agents.
- BiologySeminars in nuclear medicine
- 2012
PiB is a PET radioligand that binds selectively and with high affinity to only fibrillar forms of Aβ that has demonstrated the usefulness of assessing the Aβ plaque status of subjects many years before the clinical diagnosis of probable AD.
Amyloid imaging in Alzheimer's disease: comparison of florbetapir and Pittsburgh compound-B positron emission tomography
- MedicineJournal of Neurology, Neurosurgery & Psychiatry
- 2012
These data support the hypothesis that florbetapir-F18 provides comparable information with Pittsburgh Compound-B, and show highly significant group discrimination and correlation of regional uptake.
Amyloid-β Imaging with Pittsburgh Compound B and Florbetapir: Comparing Radiotracers and Quantification Methods
- BiologyThe Journal of Nuclear Medicine
- 2013
PiB and florbetapir retention ratios were strongly associated in the same individuals, and this relationship was consistent across several data analysis methods, despite scan–rescan intervals of more than a year.
[18F]Flutemetamol PET imaging and cortical biopsy histopathology for fibrillar amyloid β detection in living subjects with normal pressure hydrocephalus: pooled analysis of four studies
- Medicine, BiologyActa Neuropathologica
- 2012
Noninvasive in vivo PET imaging demonstrates strong concordance with histopathology for brain fibrillar amyloid β, supporting its promise as a tool to assist physicians with earlier detection of the disease process and making diagnostic decisions about concomitant AD and other diseases associated with brain amyloidsosis.
Pharmacokinetics of [18F]flutemetamol in wild-type rodents and its binding to beta amyloid deposits in a mouse model of Alzheimer’s disease
- Biology, ChemistryEuropean Journal of Nuclear Medicine and Molecular Imaging
- 2012
Based on its pharmacokinetic profile, [18F]flutemetamol showed potential as a PET tracer for preclinical imaging and showed good brain uptake and was bound to Aβ deposits in the brain of Tg2576 mice, however, its high lipophilicity might complicate the analysis of PET data, particularly in small-animal imaging.