Imaging β-amyloid using [18F]flutemetamol positron emission tomography: from dosimetry to clinical diagnosis

@article{Heurling2015ImagingU,
  title={Imaging $\beta$-amyloid using [18F]flutemetamol positron emission tomography: from dosimetry to clinical diagnosis},
  author={Kerstin Heurling and Antoine Leuzy and Eduardo R. Zimmer and Mark Lubberink and Agneta Nordberg},
  journal={European Journal of Nuclear Medicine and Molecular Imaging},
  year={2015},
  volume={43},
  pages={362-373}
}
In Alzheimer’s disease (AD), the deposition of β-amyloid (Aβ) is hypothesized to result in a series of secondary neurodegenerative processes, leading ultimately to synaptic dysfunction and neuronal loss. Since the advent of the first Aβ-specific positron emission tomography (PET) ligand, 11C-Pittsburgh compound B ([11C]PIB), several 18F ligands have been developed that circumvent the limitations of [11C]PIB tied to its short half-life. To date, three such compounds have been approved for… 
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29 Citations

[18F]Amylovis as a Potential PET Probe for β-Amyloid Plaque: Synthesis, In Silico, In vitro and In vivo Evaluations
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The in silico, in vitro and in vivo results justify that [18F]Amylovis should be studied as a promissory PET imaging agent to detect the presence of Aβ senile plaques.
Discovery and preclinical characterization of [18F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer’s disease and other tauopathies
PurposeTau deposition is a key pathological feature of Alzheimer’s disease (AD) and other neurodegenerative disorders. The spreading of tau neurofibrillary tangles across defined brain regions…
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The findings of this review confirm the importance of 99mTc-labeled small molecules for AD imaging and future studies based on the pharmacophore of these designed compounds are needed for improvement of these molecules for clinical application.
Clinical validity of increased cortical uptake of amyloid ligands on PET as a biomarker for Alzheimer's disease in the context of a structured 5-phase development framework
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TLDR
This method allows for robust and accurate registration of [18F]florbetaben images to template space, without the need for an MR image, and may prove of value in clinical and research settings.
Synthesis and biological evaluation of curcumin analogs as β-amyloid imaging agents.
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The results strongly suggested that [125I]4e might be developed into potential amyloid imaging agent for the detection of senile plaques in AD.
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Novel 1,4,7-triazacyclononane-based bifunctional chelators that incorporate a benzothiazole moiety as the Aβ-binding fragment and form charged and neutral species with 68Ga3+.
Recent progress in the development of metal complexes as β-amyloid imaging probes in the brain.
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This review has discussed various radioactive complexes of 99mTc, 68Ga, 64Cu, 89Zr, and 111In, which were designed as Aβ imaging agents for PET and single photon emission computed tomography (SPECT) imaging, non-radioactive Re and Ru complexes as A β sensors using luminescence methods, and Gd3+ complexes as contrast agents for magnetic resonance imaging (MRI).
Applications of amyloid, tau, and neuroinflammation PET imaging to Alzheimer's disease and mild cognitive impairment
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Although the majority of radiotracers showed the ability to discriminate AD and MCI patients from healthy controls, they had various limitations that prevent the recommendation of a single technique or tracer as an optimal biomarker.
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