Image-guided sampling reveals increased stroma and lower glandular complexity in mammographically dense breast tissue

Abstract

Mammographic density (MD) adjusted for age and body mass index (BMI) is a strong heritable breast cancer risk factor; however, its biological basis remains elusive. Previous studies assessed MD-associated histology using random sampling approaches, despite evidence that high and low MD areas exist within a breast and are negatively correlated with respect… (More)
DOI: 10.1007/s10549-011-1346-0

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