Image-guided radiotherapy platform using single nodule conditional lung cancer mouse models

@inproceedings{HerterSprie2014ImageguidedRP,
  title={Image-guided radiotherapy platform using single nodule conditional lung cancer mouse models},
  author={Grit S. Herter-Sprie and Houari Korideck and Camilla Laulund Christensen and Jan M. Herter and Kevin Rhee and Ross Berbeco and David G. Bennett and Esra A. Akbay and David Kozono and Raymond H. Mak and G. Mike Makrigiorgos and Alec C. Kimmelman and Kwok-kin Wong},
  booktitle={Nature communications},
  year={2014}
}
Close resemblance of murine and human trials is essential to achieve the best predictive value of animal-based translational cancer research. Kras-driven genetically engineered mouse models of non-small-cell lung cancer faithfully predict the response of human lung cancers to systemic chemotherapy. Owing to development of multifocal disease, however, these models have not been usable in studies of outcomes following focal radiotherapy (RT). We report the development of a preclinical platform to… CONTINUE READING