Image-guided prostate cancer therapy using aptamer-functionalized thermally cross-linked superparamagnetic iron oxide nanoparticles.

@article{Yu2011ImageguidedPC,
  title={Image-guided prostate cancer therapy using aptamer-functionalized thermally cross-linked superparamagnetic iron oxide nanoparticles.},
  author={Mi Kyung Yu and Dongkyu Kim and In-Hyun Lee and Jee-Soo So and Yong Yeon Jeong and Sangyong Jon},
  journal={Small},
  year={2011},
  volume={7 15},
  pages={2241-9}
}
CG-rich duplex containing prostate-specific membrane antigen (PSMA) aptamer-conjugated thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPIONs) is reported as prostate cancer-specific nanotheranostic agents. These agents are capable of prostate tumor detection in vivo by magnetic resonance imaging (MRI) and selective delivery of drugs to the tumor tissue, simultaneously. The prepared PSMA-functionalized TCL-SPION via a hybridization method (Apt-hybr-TCL-SPION) exhibited… CONTINUE READING
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