Image analysis of the nuclear characteristics of emerin protein and the correlation with nuclear grooves and intranuclear cytoplasmic inclusions in lung adenocarcinoma

  title={Image analysis of the nuclear characteristics of emerin protein and the correlation with nuclear grooves and intranuclear cytoplasmic inclusions in lung adenocarcinoma},
  author={Sayaka Kobayashi and Masanao Saio and Toshio Fukuda and Kiminori Kimura and Junko Hirato and Tetsunari Oyama},
  journal={Oncology Reports},
  pages={133 - 142}
Nuclear size and shape are important components in the diagnosis of pathological specimens. However, a qualitative evaluation is typically applied rather than a quantitative evaluation technique. In the present study, we sought to evaluate the nuclear morphological characteristics of lung adenocarcinoma using whole-slide imaging (WSI) and computer-assisted image analysis (IA). We evaluated the nuclear characteristics of 106 cases of surgically resected lung adenocarcinoma according to Feulgen… 
5 Citations
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Interobserver Agreement in the Nuclear Grading of Primary Pulmonary Adenocarcinoma
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The interobserver agreement for nuclear grading is significantly higher than for histological classifications and the extent of the lepidic pattern and is a reliable prognostic indicator for small adenocarcinomas.
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Intranuclear cytoplasmic inclusions in fine‐needle aspiration smears of papillary thyroid carcinoma: A study of its morphological forms, association with nuclear grooves, and mode of formation
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The diagnostic pathology of the nuclear envelope in human cancers.
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    Advances in experimental medicine and biology
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Feulgen staining remains the gold standard for precise DNA image cytometry.
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