Image analysis of the nuclear characteristics of emerin protein and the correlation with nuclear grooves and intranuclear cytoplasmic inclusions in lung adenocarcinoma

@article{Kobayashi2019ImageAO,
  title={Image analysis of the nuclear characteristics of emerin protein and the correlation with nuclear grooves and intranuclear cytoplasmic inclusions in lung adenocarcinoma},
  author={Sayaka Kobayashi and Masanao Saio and Toshio Fukuda and Kiminori Kimura and Junko Hirato and Tetsunari Oyama},
  journal={Oncology Reports},
  year={2019},
  volume={41},
  pages={133 - 142}
}
Nuclear size and shape are important components in the diagnosis of pathological specimens. However, a qualitative evaluation is typically applied rather than a quantitative evaluation technique. In the present study, we sought to evaluate the nuclear morphological characteristics of lung adenocarcinoma using whole-slide imaging (WSI) and computer-assisted image analysis (IA). We evaluated the nuclear characteristics of 106 cases of surgically resected lung adenocarcinoma according to Feulgen… 
5 Citations
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References

SHOWING 1-10 OF 27 REFERENCES
Clinicopathologic significance of nuclear grooves and inclusions in renal cell carcinoma: image database construction and quantitative scoring.
TLDR
Nuclear grooves and inclusions are histologic components of RCCs, especially chromophobe and papillary carcinomas, and might be an independent prognostic factor for clear cell RCC.
Pleomorphism of the nuclear envelope in breast cancer: a new approach to an old problem
TLDR
Decoration of the NE might be regarded as a novel diagnostic parameter to define the grade of malignancy, which parallels and enhances that provided by routine histological procedures.
Nuclear features of infiltrating urothelial carcinoma are distinguished from low-grade noninvasive papillary urothelial carcinoma by image analysis
TLDR
The results of the present study suggest that IA in combination with WSI may be a beneficial tool for evaluating morphometric characteristics and performing semi-quantitative analysis of IHC.
Interobserver Agreement in the Nuclear Grading of Primary Pulmonary Adenocarcinoma
  • Y. Nakazato, A. Maeshima, +9 authors M. Noguchi
  • Medicine
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • 2013
TLDR
The interobserver agreement for nuclear grading is significantly higher than for histological classifications and the extent of the lepidic pattern and is a reliable prognostic indicator for small adenocarcinomas.
Computer-assisted morphometric image analysis of cells of normal oral epithelium and oral squamous cell carcinoma
TLDR
Techniques of image analysis offer an opportunity to quantify the nuclear and cell changes associated with malignancy and provide an objective basis for grading dysplasia and tumors.
Intranuclear cytoplasmic inclusions in fine‐needle aspiration smears of papillary thyroid carcinoma: A study of its morphological forms, association with nuclear grooves, and mode of formation
  • D. Das
  • Biology, Medicine
    Diagnostic cytopathology
  • 2005
TLDR
The formation of INCIs as a cytoplasmic invagination into the nucleus was shown cytomorphologically in rare cells and showed their mode of formation shown at a light microscopic level.
Role of Nuclear Morphometry in Breast Cancer and its Correlation with Cytomorphological Grading of Breast Cancer: A Study of 64 Cases
TLDR
Nuclear morphometry can be applied to augment the cytology grading of breast cancer and thus help in classifying patients into low and high-risk groups.
Emerin immunohistochemistry reveals diagnostic features of nuclear membrane arrangement in thyroid lesions
TLDR
The aim was to focus on the immunohistochemistry of emerin, a protein of the NM whose decoration best demarcates the nuclear shape.
The diagnostic pathology of the nuclear envelope in human cancers.
  • A. Fischer
  • Biology, Medicine
    Advances in experimental medicine and biology
  • 2014
TLDR
Uncovering the precise mechanistic basis for any of these lamina alterations would provide a valuable objective means for improving diagnosis, and will likely reflect new types of functional changes, relevant to particular forms of cancer.
Feulgen staining remains the gold standard for precise DNA image cytometry.
TLDR
Diagnostic or prognostic conclusions cannot be drawn from DNA measurements on Papanicolaou-stained or hematoxylin-stained specimens; Feulgen staining remains the gold standard for such purposes.
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