Image analysis of restriction enzyme fingerprint autoradiograms

  title={Image analysis of restriction enzyme fingerprint autoradiograms},
  author={J. Sulston and F. Mallett and Richard Durbin and Terry Horsnell},
  journal={Computer applications in the biosciences : CABIOS},
  volume={5 2},
A genome mapping system has been developed that reads and assembles data from clones analysed by restriction enzyme fragmentation and polyacrylamide gel electrophoresis. Input data for the system can be most effectively obtained by the use of a scanning densitometer and image-processing package, such as that described in this article. The image-processing procedure involves preliminary location of bands, cooperative tracking of lanes by correlation of adjacent bands, a precise densitometric… CONTINUE READING


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