Image analysis of platelet derived growth factor receptor-beta (PDGFRβ) expression to determine the grade and dynamics of myelofibrosis in bone marrow biopsy samples.

@article{Bedekovics2014ImageAO,
  title={Image analysis of platelet derived growth factor receptor-beta (PDGFRβ) expression to determine the grade and dynamics of myelofibrosis in bone marrow biopsy samples.},
  author={Judit Bedekovics and Szilvia Szeghalmy and L{\'i}via Beke and Attila Fazekas and Gabor Mehes},
  journal={Cytometry. Part B, Clinical cytometry},
  year={2014},
  volume={86 5},
  pages={
          319-28
        }
}
BACKGROUND Myelofibrosis (MF) is characterized by accumulation of stromal cells and extracellular matrix. Progression of fibrosis is an important clinical issue and monitoring is required for new therapeutic approaches. Currently, the quantification is based on semiquantitative evaluation of reticulin silver stained slides. We recently reported that platelet derived growth factor receptor beta (PDGFRβ) expression in fibroblasts is a useful marker of stromal activation. PDGFRβ expression based… CONTINUE READING

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