Image analysis of liver collagen using sirius red is more accurate and correlates better with serum fibrosis markers than trichrome.

@article{Huang2013ImageAO,
  title={Image analysis of liver collagen using sirius red is more accurate and correlates better with serum fibrosis markers than trichrome.},
  author={Yi Huang and Willem Bastiaan de Boer and Leon Anton Adams and Gerry C Macquillan and E. V. Rossi and Paul Rigby and Spiro Costa Raftopoulos and Max Bulsara and Gary P. Jeffrey},
  journal={Liver international : official journal of the International Association for the Study of the Liver},
  year={2013},
  volume={33 8},
  pages={1249-56}
}
BACKGROUND Collagen proportional area (CPA) determined by quantitative digital image analysis better quantifies liver fibrosis than histological stage; however, its clinical use has been limited by non-standardized methods. AIM This study aimed to compare CPA obtained using different staining methods, magnifications and biopsy sizes. METHODS Two hundred and forty-nine patients with chronic hepatitis C who had a liver biopsy and serum fibrosis markers performed were included. CPA was… CONTINUE READING
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