Image-aided Suicide Gene Therapy Utilizing Multifunctional hTERT-targeting Adenovirus for Clinical Translation in Hepatocellular Carcinoma.

@article{Kim2016ImageaidedSG,
  title={Image-aided Suicide Gene Therapy Utilizing Multifunctional hTERT-targeting Adenovirus for Clinical Translation in Hepatocellular Carcinoma.},
  author={Yun-Hee Kim and Kyung Tae Kim and Sang-Jin Lee and Seung-Hee Hong and Ju Young Moon and Eun Kyung Yoon and Sukyoung Kim and Eun Ok Kim and Se Hun Kang and Seok Ki Kim and Sun Il Choi and Sung Ho Goh and Daehong Kim and Seong-Wook Lee and Mi Ha Ju and Jin Sook Jeong and In-Hoo Kim},
  journal={Theranostics},
  year={2016},
  volume={6 3},
  pages={357-68}
}
Trans-splicing ribozyme enables to sense and reprogram target RNA into therapeutic transgene and thereby becomes a good sensing device for detection of cancer cells, judging from transgene expression. Previously we proposed PEPCK-Rz-HSVtk (PRT), hTERT targeting trans-splicing ribozyme (Rz) driven by liver-specific promoter phosphoenolpyruvate carboxykinase… CONTINUE READING