Iloprost, a prostacyclin analog, inhibits the invasion of ovarian cancer cells by downregulating matrix metallopeptidase-2 (MMP-2) through the IP-dependent pathway.

@article{Ahn2018IloprostAP,
  title={Iloprost, a prostacyclin analog, inhibits the invasion of ovarian cancer cells by downregulating matrix metallopeptidase-2 (MMP-2) through the IP-dependent pathway.},
  author={J. Ahn and K. Lee and Y. S. Choi and Jung-Hye Choi},
  journal={Prostaglandins & other lipid mediators},
  year={2018},
  volume={134},
  pages={
          47-56
        }
}
  • J. Ahn, K. Lee, +1 author Jung-Hye Choi
  • Published 2018
  • Chemistry, Medicine
  • Prostaglandins & other lipid mediators
  • Recent studies have shown that a bioactive lipid prostacyclin (PGI2) plays a role in various cancers, including lung cancer. However, the specific function of PGI2 in ovarian cancer progression has not been determined. This study investigated the effects of PGI2 on cell growth, migration, and invasion in ovarian cancer cells using iloprost, a stable PGI2 analog. Iloprost significantly inhibited migration and invasion, but not cell growth, in a dose-dependent manner in human ovarian cancer cells… CONTINUE READING
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