Illustrative case using the RISK21 roadmap and matrix: prioritization for evaluation of chemicals found in drinking water

@article{Wolf2015IllustrativeCU,
  title={Illustrative case using the RISK21 roadmap and matrix: prioritization for evaluation of chemicals found in drinking water},
  author={Douglas C. Wolf and Ammie N. Bachman and Gordon Barrett and Cheryl A. Bellin and Jay I. Goodman and Elke Jensen and Angelo Moretto and Tami S McMullin and Timothy Pastoor and Rita S. Schoeny and Brian Slezak and Korinna Wend and Michelle R. Embry},
  journal={Critical Reviews in Toxicology},
  year={2015},
  volume={46},
  pages={43 - 53}
}
ABSTRACT The HESI-led RISK21 effort has developed a framework supporting the use of twenty-first century technology in obtaining and using information for chemical risk assessment. This framework represents a problem formulation-based, exposure-driven, tiered data acquisition approach that leads to an informed decision on human health safety to be made when sufficient evidence is available. It provides a transparent and consistent approach to evaluate information in order to maximize the… 
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11 Citations
Highly Influential Citations
1
Background Citations
5
Methods Citations
3

11 Citations

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Letter to the editor RE: Wolf et al.1

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  • 2019

Response to letter to the editor from Chappelle, Spence, and Tury concerning Wolf et al. 2016: Illustrative case using the RISK21 roadmap and matrix: prioritization for evaluation of chemicals found in drinking water. 2016, Crit. Rev. Toxicol. Vol 46: 43–53

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The evaluation demonstrated the concept of using existing information within the RISK21 matrix to drive the generation of additional data using a value-of-information approach and showed how new methodology such as the use of in vitro studies and assays could be used to answer the specific questions which arise through the useof the matrix.

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