Illuminating the silence: understanding the structure and function of small RNAs

  title={Illuminating the silence: understanding the structure and function of small RNAs},
  author={T. Rana},
  journal={Nature Reviews Molecular Cell Biology},
  • T. Rana
  • Published 2007
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • RNA interference (RNAi) is triggered by double-stranded RNA helices that have been introduced exogenously into cells as small interfering (si)RNAs or that have been produced endogenously from small non-coding RNAs known as microRNAs (miRNAs). RNAi has become a standard experimental tool and its therapeutic potential is being aggressively harnessed. Understanding the structure and function of small RNAs, such as siRNAs and miRNAs, that trigger RNAi has shed light on the RNAi machinery. In… CONTINUE READING

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