Illuminating the secretory pathway: when do we need vesicles?

@article{Stephens2001IlluminatingTS,
  title={Illuminating the secretory pathway: when do we need vesicles?},
  author={David John Stephens and Rainer Pepperkok},
  journal={Journal of cell science},
  year={2001},
  volume={114 Pt 6},
  pages={1053-9}
}
Recent studies using GFP-tagged markers and time-lapse microscopy have allowed direct visualisation of membrane traffic in the secretory pathway in living mammalian cells. This work shows that larger membrane structures, 300-500 nm in size, are the vehicles responsible for long distance, microtubule-dependent ER-to-Golgi and trans-Golgi to plasma membrane transport of secretory markers. At least two retrograde transport pathways from the Golgi to the ER exist, both of which are proposed to… CONTINUE READING

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