Illuminating the secretory pathway: when do we need vesicles?

  title={Illuminating the secretory pathway: when do we need vesicles?},
  author={David John Stephens and Rainer Pepperkok},
  journal={Journal of cell science},
  volume={114 Pt 6},
Recent studies using GFP-tagged markers and time-lapse microscopy have allowed direct visualisation of membrane traffic in the secretory pathway in living mammalian cells. This work shows that larger membrane structures, 300-500 nm in size, are the vehicles responsible for long distance, microtubule-dependent ER-to-Golgi and trans-Golgi to plasma membrane transport of secretory markers. At least two retrograde transport pathways from the Golgi to the ER exist, both of which are proposed to… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 40 extracted citations

Cln 8-from Gene to Protein

View 20 Excerpts
Highly Influenced

Hrd1 participates in the regulation of collagen I synthesis in renal fibrosis

Molecular and Cellular Biochemistry • 2013
View 13 Excerpts
Highly Influenced

ARF1 and SAR1 GTPases in Endomembrane Trafficking in Plants

International journal of molecular sciences • 2013
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 58 references

Coat proteins and vesicle budding.

Science • 1996
View 17 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…