Illuminating the diversity of aromatic polyketide synthases in Aspergillus nidulans.

  title={Illuminating the diversity of aromatic polyketide synthases in Aspergillus nidulans.},
  author={Manmeet Ahuja and Yi-Ming Chiang and S Chang and Mike B Praseuth and Ruth A Entwistle and J. Fern{\'a}ndez S{\'a}nchez and Hsien-Chun Lo and Hsu-Hua Yeh and Berl R Oakley and Clay Chia Chun Wang},
  journal={Journal of the American Chemical Society},
  volume={134 19},
Genome sequencing has revealed that fungi have the ability to synthesize many more natural products (NPs) than are currently known, but methods for obtaining suitable expression of NPs have been inadequate. We have developed a successful strategy that bypasses normal regulatory mechanisms. By efficient gene targeting, we have replaced, en masse, the promoters of nonreducing polyketide synthase (NR-PKS) genes, key genes in NP biosynthetic pathways, and other genes necessary for NR-PKS product… CONTINUE READING


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Handbook of Toxic Fungal Metabolites

RJ. Cole, Cox, RH, editors
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