Illuminating the Circadian Clock in Monarch Butterfly Migration

  title={Illuminating the Circadian Clock in Monarch Butterfly Migration},
  author={Oren Froy and Anthony L Gotter and Amy L. Casselman and Steven M. Reppert},
  pages={1303 - 1305}
Migratory monarch butterflies use a time-compensated Sun compass to navigate to their overwintering grounds in Mexico. Here, we report that constant light, which disrupts circadian clock function at both the behavioral and molecular levels in monarchs, also disrupts the time-compensated component of flight navigation. We further show that ultraviolet light is important for flight navigation but is not required for photic entrainment of circadian rhythms. Tracing these distinct light-input… 

The Circadian Clock in Monarch Butterfly: A Tale of Two CRYs: A Dissertation

This work provided strong evidence supporting monarch CRY2’s role as a major circadian clock repressor and identified a protein-protein protective interaction cascade underlying the CRY1-mediated resetting of the molecular oscillator in DpN1 cells, which advanced the understanding of monarch circadian clock mechanism.

Cryptochromes Define a Novel Circadian Clock Mechanism in Monarch Butterflies That May Underlie Sun Compass Navigation

The results define a novel, CRY-centric clock mechanism in the monarch in which CRY1 likely functions as a blue-light photoreceptor for entrainment, whereas CRY2 functions within the clockwork as the transcriptional repressor of a negative transcriptional feedback loop.

The ancestral circadian clock of monarch butterflies: role in time-compensated sun compass orientation.

  • S. Reppert
  • Biology
    Cold Spring Harbor symposia on quantitative biology
  • 2007
The monarch butterfly may use the CRY proteins as components of the circadian mechanism and also as output molecules that connect the clock to various aspects of the sun compass apparatus.

Antennal Circadian Clocks Coordinate Sun Compass Orientation in Migratory Monarch Butterflies

It is shown that the antennae are necessary for proper time-compensated Sun Compass orientation in migratory monarch butterflies, that antennal clocks exist in monarchs, and that they likely provide the primary timing mechanism for Sun compass orientation.

Discordant timing between antennae disrupts sun compass orientation in migratory monarch butterflies

This work shows that clock outputs from each antenna are processed and integrated together in the monarch time-compensated sun compass circuit, which is a novel example of the regulation of a brain-driven behaviour by paired organs.

Neurobiology of Monarch Butterfly Migration.

The monarch butterfly has emerged as a model system to study the neural, molecular, and genetic basis of long-distance animal migration.

Unraveling Traveling

The monarch butterfly uses a time-compensated clock in its antennae to calculate seasonal migration routes relative to the Sun's position, and on page 1700 of this issue, Merlin et al. reveal that it's in the antennae.



Virtual migration in tethered flying monarch butterflies reveals their orientation mechanisms

  • H. MouritsenB. Frost
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2002
Long segments of virtual flight paths of tethered, flying, migratory monarch butterflies were reconstructed, and by advancing or retarding the butterflies' circadian clocks, it is shown that they possess a time-compensated sun compass.

Polarization vision--a uniform sensory capacity?

  • R. Wehner
  • Physics
    The Journal of experimental biology
  • 2001
The hypothesis entertained in this account is that polarization vision comes in various guises, and that the answer to the question posed in the title is most probably no.


Recently, many cellular oncogenes were identified in human cancerous cells by the DNA transfection method, some of which were found to contain sequences related with already known viral oncogenees.

IL-13受体α2降低血吸虫病肉芽肿的炎症反应并延长宿主存活时间[英]/Mentink-Kane MM,Cheever AW,Thompson RW,et al//Proc Natl Acad Sci U S A


Monarch butterfly orientation: missing pieces of a magnificent puzzle

  • Brower
  • Environmental Science
    The Journal of experimental biology
  • 1996
A new hypothesis is presented that the orientation of adult monarchs undergoes a continual clockwise shifting throughout the 3-5 generations, rotating by 360 in the course of the year, consistent with the timing of arrivals and the relative abundance of the successive generations of monarchs throughout eastern North America.

Time zones: a comparative genetics of circadian clocks

The circadian clock is a widespread cellular mechanism that underlies diverse rhythmic functions in organisms from bacteria and fungi, to plants and animals, and the weight of evidence favours their independent evolutionary origins in different kingdoms.