Illness-induced hyperalgesia is mediated by a spinal NMDA-nitric oxide cascade.

  title={Illness-induced hyperalgesia is mediated by a spinal NMDA-nitric oxide cascade.},
  author={Eric P. Wiertelak and L E Furness and Linda R. Watkins and Steven F. Maier},
  journal={Brain research},
  volume={664 1-2},
A variety of experimental manipulations produce enhanced pain responsivity. Recent work has demonstrated that activation of N-methyl-D-aspartate (NMDA) receptors in the spinal cord can produce persistent enhancement of pain via production of nitric oxide and/or prostaglandins. To date, the behavioral paradigms used to study NMDA mediated hyperalgesia have all involved direct excitation of spinal cord dorsal horn neurons via activation of primary nociceptive afferents. The present series of… CONTINUE READING


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