Illegitimate recombination in Xenopus: characterization of end-joined junctions.

  title={Illegitimate recombination in Xenopus: characterization of end-joined junctions.},
  author={Carl W. Lehman and Jonathan K. Trautman and Dana Carroll},
  journal={Nucleic acids research},
  volume={22 3},
When linear DNAs are injected into Xenopus laevis eggs, they are converted into several different kinds of recombination products. Some molecules undergo homologous recombination by a resection-annealing mechanism; some ends are precisely ligated; and some ends are joined by illegitimate means. The homologous and illegitimate products are also generated in nuclear extracts from stage VI Xenopus oocytes. In order to gain insight into the mechanism(s) of illegitimate end joining, we amplified… CONTINUE READING


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