Ilimaquinone induces death receptor expression and sensitizes human colon cancer cells to TRAIL-induced apoptosis through activation of ROS-ERK/p38 MAPK-CHOP signaling pathways.

@article{Do2014IlimaquinoneID,
  title={Ilimaquinone induces death receptor expression and sensitizes human colon cancer cells to TRAIL-induced apoptosis through activation of ROS-ERK/p38 MAPK-CHOP signaling pathways.},
  author={Minh Truong Do and MinKyun Na and Hyung Gyun Kim and Tilak Khanal and Jae Ho Choi and Sun Woo Jin and Seok Hoon Oh and In Hyun Hwang and Young Chul Chung and Hee Suk Kim and Tae Cheon Jeong and Hye Gwang Jeong},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2014},
  volume={71},
  pages={51-9}
}
TRAIL induces apoptosis in a variety of tumor cells. However, development of resistance to TRAIL is a major obstacle to more effective cancer treatment. Therefore, novel pharmacological agents that enhance sensitivity to TRAIL are necessary. In the present study, we investigated the molecular mechanisms by which ilimaquinone isolated from a sea sponge sensitizes human colon cancer cells to TRAIL. Ilimaquinone pretreatment significantly enhanced TRAIL-induced apoptosis in HCT 116 cells and… CONTINUE READING
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