Ileitis alters neuronal and enteroendocrine signalling in guinea pig distal colon.

@article{OHara2007IleitisAN,
  title={Ileitis alters neuronal and enteroendocrine signalling in guinea pig distal colon.},
  author={Jennifer R O'Hara and A E Lomax and G M Mawe and Keith A Sharkey},
  journal={Gut},
  year={2007},
  volume={56 2},
  pages={186-94}
}
BACKGROUND AND AIMS Intestinal inflammation alters neuronal and enteroendocrine signalling, leading to functional adaptations in the inflamed bowel. Human studies have reported functional alterations at sites distant from active inflammation. Our aims were to determine whether neuronal and enteroendocrine signalling are altered in the uninflamed colon during ileitis. METHODS We used neurophysiological, immunohistochemical, biochemical and Ussing chamber techniques to examine the effect of 2,4… CONTINUE READING

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