Ile50Val variant of IL4Rα upregulates IgE synthesis and associates with atopic asthma

  title={Ile50Val variant of IL4Rα upregulates IgE synthesis and associates with atopic asthma},
  author={Hiromichi Mitsuyasu and Kenji Izuhara and Xiao-quan Mao and Peisong Gao and Yojirou Arinobu and Tadao Enomoto and Mitsuru Kawai and Sei Sasaki and Yasuhiro Dake and Naotaka Hamasaki and Taro Shirakawa and Julian M. Hopkin},
  journal={Nature Genetics},
Atopy is an immune disorder characterized by heightened immunoglobulin E (IgE) production and leads to the clinical disorders of asthma, eczema and rhinitis1. Interleukin 4 (IL4) is a pleiotropic cytokine which plays a crucial role in IgEdependent atopic disorders2; it is central to B cells switching to IgE antibody production and to the maturation of T-helper cells to the Th2 phenotype (type-2 Thelper lymphocyte). Human IL4 operates through the IL4 receptor (IL4R) and thereby Stat6 (signal… CONTINUE READING


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Nature America Inc. • © 1 99 8 N at u re A m er ic a In c. • h tt p :/ /g en et ic s

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Clin. Exp. Allergy 28, • 1998

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