Ile481 from the guinea pig alpha-subunit plays a major role in the activation of ENaC by cpt-cAMP.

@article{Renauld2008Ile481FT,
  title={Ile481 from the guinea pig alpha-subunit plays a major role in the activation of ENaC by cpt-cAMP.},
  author={St{\'e}phane Renauld and Redouane Allache and Chraibi Chraibi},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year={2008},
  volume={22 1-4},
  pages={101-8}
}
The epithelial sodium channel (ENaC) is the major rate-limiting step for vasopressin and aldosterone sensitive Na(+) reabsorption across kidney epithelia. Recently, ENaC activity was shown to be modulated by extracellular factors such as proteases, Na(+) ion and several other elements. However, the molecular mechanisms of these actions remain unclear. We and others have shown that ENaC composed of the guinea-pig alpha-subunit (alphagp), and the beta gamma rat subunits (betargammar) could be… CONTINUE READING
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Nephrol Hypertens 2007;16:444-50

  • RP Hughey, GM Mueller, JB Bruns
  • 2007

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