Il-12: keeping cell-mediated immunity alive.

  title={Il-12: keeping cell-mediated immunity alive.},
  author={Audrey Y. Park and Phillip Scott},
  journal={Scandinavian journal of immunology},
  volume={53 6},
Interleukin (IL)-12 has dominated the field of cell-mediated immunity since its discovery more than 10 years ago, and clearly plays an essential role in the development of Th1 cells under a variety of conditions. Recent studies now indicate that the importance of IL-12 is not limited to initiating an immune response, but may contribute to maintaining immunity. Thus, Th1 responses rapidly wane in the absence of IL-12, leading to a loss in protective immunity against intracellular pathogens, such… CONTINUE READING

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