Ikaros stability and pericentromeric localization are regulated by protein phosphatase 1.

@article{Popescu2009IkarosSA,
  title={Ikaros stability and pericentromeric localization are regulated by protein phosphatase 1.},
  author={Marcela Popescu and Zafer Gurel and Tapani Ronni and Chunhua Song and Ka Ying Sharon Hung and Kimberly J Payne and Sinisa Dovat},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 20},
  pages={13869-80}
}
Ikaros encodes a zinc finger protein that is involved in gene regulation and chromatin remodeling. The majority of Ikaros localizes at pericentromeric heterochromatin (PC-HC) where it regulates expression of target genes. Ikaros function is controlled by posttranslational modification. Phosphorylation of Ikaros by CK2 kinase determines its ability to bind DNA and exert cell cycle control as well as its subcellular localization. We report that Ikaros interacts with protein phosphatase 1 (PP1… CONTINUE READING

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