Ikaros sets the potential for Th17 lineage gene expression through effects on chromatin state in early T cell development.

@article{Wong2013IkarosST,
  title={Ikaros sets the potential for Th17 lineage gene expression through effects on chromatin state in early T cell development.},
  author={Larry Y. Wong and Julianne K. Hatfield and Melissa A Brown},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 49},
  pages={35170-9}
}
Th17 cells are important effectors of immunity to extracellular pathogens, particularly at mucosal surfaces, but they can also contribute to pathologic tissue inflammation and autoimmunity. Defining the multitude of factors that influence their development is therefore of paramount importance. Our previous studies using Ikaros(-/-) CD4+ T cells implicated Ikaros in Th1 versus Th2 lineage decisions. Here we demonstrate that Ikaros also regulates Th17 differentiation through its ability to… CONTINUE READING

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