Ikaros null mice display defects in T cell selection and CD4 versus CD8 lineage decisions.

@article{Urban2004IkarosNM,
  title={Ikaros null mice display defects in T cell selection and CD4 versus CD8 lineage decisions.},
  author={Julie Ann Urban and Susan Winandy},
  journal={Journal of immunology},
  year={2004},
  volume={173 7},
  pages={
          4470-8
        }
}
Previous evidence suggested that the hemopoietic-specific nuclear factor Ikaros regulates TCR signaling thresholds in mature T cells. In this study, we test the hypothesis that Ikaros also sets TCR signaling thresholds to regulate selection events and CD4 vs CD8 lineage determination in developing thymocytes. Ikaros null mice were crossed to three lines of TCR-transgenic mice, and positive selection, negative selection, and CD4 vs CD8 lineage decisions were analyzed. Mice expressing a… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 27 CITATIONS