Ikaros limits follicular B cell activation by regulating B cell receptor signaling pathways.

Abstract

The Ikaros transcription factor is essential for early B cell development, but its effect on mature B cells is debated. We show that Ikaros is required to limit the response of naive splenic B cells to B cell receptor signals. Ikaros deficient follicular B cells grow larger and enter cell cycle faster after anti-IgM stimulation. Unstimulated mutant B cells… (More)
DOI: 10.1016/j.bbrc.2016.01.060

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