Ikaros and chromatin regulation in early hematopoiesis.

  title={Ikaros and chromatin regulation in early hematopoiesis.},
  author={Samuel Yao-Ming Ng and Toshimi Yoshida and Katia Georgopoulos},
  journal={Current opinion in immunology},
  volume={19 2},
Hematopoiesis is the developmental process by which all blood and immune cells are generated. A decade-old scheme has supported an early and complete separation of the erythro-myeloid from the lymphoid lineages. Recent advances have re-drawn this map, separating lymphoid and myeloid from erythroid programs early in development. Subsequently, the fate restriction of both the lympho-myeloid and the erythro-megakaryocyte progenitors is dependent on Ikaros and its associated chromatin regulators… CONTINUE READING


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