• Medicine
  • Published in
    Molecular and cellular…
    2004

IkappaB kinase is an essential component of the Tpl2 signaling pathway.

@article{Waterfield2004IkappaBKI,
  title={IkappaB kinase is an essential component of the Tpl2 signaling pathway.},
  author={Michael Waterfield and Wei Jin and William W. Reiley and Minying Zhang and Shao-Cong Sun},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 13},
  pages={
          6040-8
        }
}
IkappaB kinase (IKK), a key regulator of immune and inflammatory responses, is known as an effector kinase mediating activation of the transcription factor NF-kappaB. Whether IKK also participates in other signaling events is not known. Here we show that IKK serves as an essential component of a signaling pathway that involves activation of the Tpl2 kinase and its downstream targets, MEK1 and ERK. Inhibition of IKKbeta in macrophages eliminates Tpl2 activation and ERK phosphorylation induced by… CONTINUE READING

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