Ii-Key/HER-2/neu(776-90) hybrid peptides induce more effective immunological responses over the native peptide in lymphocyte cultures from patients with HER-2/neu+ tumors

@article{Sotiriadou2006IiKeyHER2neu77690HP,
  title={Ii-Key/HER-2/neu(776-90) hybrid peptides induce more effective immunological responses over the native peptide in lymphocyte cultures from patients with HER-2/neu+ tumors},
  author={Nectaria N. Sotiriadou and Nikoletta L. Kallinteris and Angelos D. Gritzapis and Ioannis F. Voutsas and Michael Papamichail and Eric von Hofe and Robert E. Humphreys and Theodoros Pavlis and Sonia Cristina Gualtieri de Andrade Perez and Constantin N. Baxevanis},
  journal={Cancer Immunology, Immunotherapy},
  year={2006},
  volume={56},
  pages={601-613}
}
We have demonstrated that coupling an immunoregulatory segment of the MHC class II-associated invariant chain (Ii), the Ii-Key peptide, to a promiscuous MHC class II epitope significantly enhances its presentation to CD4+ T cells. Here, a series of homologous Ii-Key/HER-2/neu(776-90) hybrid peptides, varying systematically in the length of the epitope(s… CONTINUE READING