Ii Chain Controls the Transport of Major Histocompatibility Complex Class II Molecules to and from Lysosomes

@article{Brachet1997IiCC,
  title={Ii Chain Controls the Transport of Major Histocompatibility Complex Class II Molecules to and from Lysosomes},
  author={Val{\'e}rie Brachet and Graça Raposo and S{\'e}bastian Amigorena and Ira Mellman},
  journal={The Journal of Cell Biology},
  year={1997},
  volume={137},
  pages={51 - 65}
}
Major histocompatibility complex class II molecules are synthesized as a nonameric complex consisting of three alpha beta dimers associated with a trimer of invariant (Ii) chains. After exiting the TGN, a targeting signal in the Ii chain cytoplasmic domain directs the complex to endosomes where Ii chain is proteolytically processed and removed, allowing class II molecules to bind antigenic peptides before reaching the cell surface. Ii chain dissociation and peptide binding are thought to occur… CONTINUE READING

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