Iguratimod for the treatment of rheumatoid arthritis in Japan

  title={Iguratimod for the treatment of rheumatoid arthritis in Japan},
  author={K. Tanaka and Tomonobu Yamaguchi and M. Hara},
  journal={Expert Review of Clinical Immunology},
  pages={565 - 573}
  • K. Tanaka, Tomonobu Yamaguchi, M. Hara
  • Published 2015
  • Medicine
  • Expert Review of Clinical Immunology
  • Iguratimod (IGU), a small-molecule compound, was developed as a disease-modifying antirheumatic drug in Japan. The pharmacological studies showed that inhibition of the production of cytokines and immunoglobulins mainly contributes to its improvement effect on animal arthritis models. The first clinical study of IGU in Japanese patients with rheumatoid arthritis was started in 1992 and Phase III studies were started in 1998. From the results of Phase II studies, a dose-escalating regimen was… CONTINUE READING
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