Igs expressed by chronic lymphocytic leukemia B cells show limited binding-site structure variability.

@article{Marcatili2013IgsEB,
  title={Igs expressed by chronic lymphocytic leukemia B cells show limited binding-site structure variability.},
  author={Paolo Marcatili and Fabio Ghiotto and Claudya Tenca and Anna Chailyan and Andrea Nicola Mazzarello and Xiao-Jie Yan and Monica L Colombo and Emilia Albesiano and Davide Bagnara and Giovanna Cutrona and Fortunato Morabito and Silvia Bruno and Manlio Ferrarini and Nicholas Chiorazzi and Anna Tramontano and Franco Fais},
  journal={Journal of immunology},
  year={2013},
  volume={190 11},
  pages={5771-8}
}
Ag selection has been suggested to play a role in chronic lymphocytic leukemia (CLL) pathogenesis, but no large-scale analysis has been performed so far on the structure of the Ag-binding sites (ABSs) of leukemic cell Igs. We sequenced both H and L chain V(D)J rearrangements from 366 CLL patients and modeled their three-dimensional structures. The resulting… CONTINUE READING