IglC and PdpA Are Important for Promoting Francisella Invasion and Intracellular Growth in Epithelial Cells

@inproceedings{Law2014IglCAP,
  title={IglC and PdpA Are Important for Promoting Francisella Invasion and Intracellular Growth in Epithelial Cells},
  author={Hong T. Law and Aarati Sriram and Charlotte Fevang and Eli Beauford Nix and Francis E Nano and Julian A Guttman},
  booktitle={PloS one},
  year={2014}
}
The highly infectious bacteria, Francisella tularensis, colonize a variety of organs and replicate within both phagocytic as well as non-phagocytic cells, to cause the disease tularemia. These microbes contain a conserved cluster of important virulence genes referred to as the Francisella Pathogenicity Island (FPI). Two of the most characterized FPI genes, iglC and pdpA, play a central role in bacterial survival and proliferation within phagocytes, but do not influence bacterial internalization… CONTINUE READING
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