IgVH-genes analysis from psoriatic arthritis shows involvement of antigen-activated synovial B-lymphocytes

Abstract

The pathogenesis of psoriatic arthritis (PA), which occurs in 5–7% of patients with psoriasis vulgaris, is enigmatic. There are no molecular data about synovial B-cells of chronic synovitis of PA. In order to understand the B-cell response in PA, we analysed IgVH genes and specified replacement to silent mutation (R/S) ratios of the complementarity… (More)
DOI: 10.1007/s00393-002-0415-5

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