IgM antibodies to apoptosis-associated determinants recruit C1q and enhance dendritic cell phagocytosis of apoptotic cells.

@article{Chen2009IgMAT,
  title={IgM antibodies to apoptosis-associated determinants recruit C1q and enhance dendritic cell phagocytosis of apoptotic cells.},
  author={Yifang Chen and Yong-Beom Park and Ekta Jadon Patel and Gregg J Silverman},
  journal={Journal of immunology},
  year={2009},
  volume={182 10},
  pages={6031-43}
}
Natural Abs, which arise without known immune exposure, have been described that specifically recognize cells dying from apoptosis, but their role in innate immunity remains poorly understood. Herein, we show that the immune response to neoantigenic determinants on apoptotic thymocytes is dominated by Abs to oxidation-associated Ags, phosphorylcholine (PC), a head group that becomes exposed during programmed cell death, and malondialdehyde (MDA), a reactive aldehyde degradation product of… CONTINUE READING

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