IgM(+) memory B cell expression predicts HIV-associated cryptococcosis status.

@article{Subramaniam2009IgMMB,
  title={IgM(+) memory B cell expression predicts HIV-associated cryptococcosis status.},
  author={Krishanthi S. Subramaniam and Brian A. Metzger and Lawrence H Hanau and Alice Y. Guh and Lisa M Rucker and Sheila Badri and Liise-anne Pirofski},
  journal={The Journal of infectious diseases},
  year={2009},
  volume={200 2},
  pages={244-51}
}
BACKGROUND The role of B cells in resistance to Cryptococcus neoformans disease (i.e., cryptococcosis) is unknown. Given evidence that IgM(+) memory B cells are required for immunity to other encapsulated pathogens, we hypothesized that these cells might contribute to resistance to cryptococcosis. METHODS We compared levels of IgM expression on memory B cells in 29 HIV-infected individuals who had a history of cryptococcosis (the HIV+CN+ group) with levels in 30 human immunodeficiency virus… CONTINUE READING