IgH DJ rearrangements within T-ALL correlate with cCD79a expression, an immature/TCRgammadelta phenotype and absence of IL7Ralpha/CD127 expression.

@article{Asnafi2004IgHDR,
  title={IgH DJ rearrangements within T-ALL correlate with cCD79a expression, an immature/TCRgammadelta phenotype and absence of IL7Ralpha/CD127 expression.},
  author={Vahid Asnafi and Khe{\"i}ra Beldjord and Richard Garand and Corinne Millien and Mariem Bahloul and P LeTutour and Luc Douay and Françoise Valensi and E A Macintyre},
  journal={Leukemia},
  year={2004},
  volume={18 12},
  pages={1997-2001}
}
cCD79a and IgH VDJ/DJ rearrangements are considered to be relatively specific for B lymphoid precursors. We looked for both in cCD3+, CD7+, CD19- T-ALLs classified by TCR status into alphabeta or gammadelta/immature (IM) lineages, with individualization of HOX11L2+ T-ALLs since they represent an intermediate alphabeta/gammadelta category. cCD79a was expressed at low levels in 47% of T-ALL and was most frequent in IMgamma T-ALLs. IgH rearrangements were common in gammadelta/IM (45%) and HOX11L2… CONTINUE READING