IgG4 anti-neurofascin155 antibodies in chronic inflammatory demyelinating polyradiculoneuropathy: Clinical significance and diagnostic utility of a conventional assay.

@article{Kadoya2016IgG4AA,
  title={IgG4 anti-neurofascin155 antibodies in chronic inflammatory demyelinating polyradiculoneuropathy: Clinical significance and diagnostic utility of a conventional assay.},
  author={Masato Kadoya and Kenichi Kaida and Haruki Koike and Hiroshi Takazaki and Hidenori Ogata and Kota Moriguchi and Jun Shimizu and Eiichiro Nagata and Shunya Takizawa and Atsuro Chiba and Ryo Yamasaki and Jun-ichi Kira and Gen Sobue and Katsunori Ikewaki},
  journal={Journal of neuroimmunology},
  year={2016},
  volume={301},
  pages={16-22}
}
We aimed to validate the diagnostic utility of enzyme-linked immunosorbent assay (ELISA) for the detection of anti-neurofascin (NF) 155 antibody in 191 patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Human NF155-based ELISA clearly distinguished between anti-NF155 antibody-positive and -negative sera. Fifteen CIDP patients (8%) were IgG4 anti-human NF155 antibody-positive, which were confirmed by western blot, cell-based assay and immunohistochemical study. None of… CONTINUE READING
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