IgG2 inhibits HIV-1 internalization by monocytes, and IgG subclass binding is affected by gp120 glycosylation.

@article{Forthal2011IgG2IH,
  title={IgG2 inhibits HIV-1 internalization by monocytes, and IgG subclass binding is affected by gp120 glycosylation.},
  author={Donald N Forthal and Gary R Landucci and Haitao Ding and John C Kappes and Angela Yee-Moon Wang and Irene Thung and Tran B. Phan},
  journal={AIDS},
  year={2011},
  volume={25 17},
  pages={2099-104}
}
OBJECTIVES To determine the effect of IgG2 opsonization on internalization of HIV-1 virus-like particles (VLPs) by monocytes and to determine the effect of gp120 glycosylation on IgG subclass binding. DESIGN Fc-Fcγ receptor (FcγR) interactions are important in antibody-mediated protection from lentivirus infection. Such interactions are influenced by IgG subclass, with IgG2 having low affinity to most FcγRs. We determined the impact of IgG2 on internalization of antibody-opsonized VLPs. It is… CONTINUE READING

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