IgG2 Antibodies against a Clinical Grade Plasmodium falciparum CSP Vaccine Antigen Associate with Protection against Transgenic Sporozoite Challenge in Mice

@inproceedings{Schwenk2014IgG2AA,
  title={IgG2 Antibodies against a Clinical Grade Plasmodium falciparum CSP Vaccine Antigen Associate with Protection against Transgenic Sporozoite Challenge in Mice},
  author={Robert Schwenk and Margot DeBot and Michael H Porter and Jennifer Nikki and Lisa Rein and Roberta Spaccapelo and Andrea Crisanti and Paul P D Wightman and Christian F. Ockenhouse and Sheetij Dutta},
  booktitle={PloS one},
  year={2014}
}
The availability of a highly purified and well characterized circumsporozoite protein (CSP) is essential to improve upon the partial success of recombinant CSP-based malaria vaccine candidates. Soluble, near full-length, Plasmodium falciparum CSP vaccine antigen (CS/D) was produced in E. coli under bio-production conditions that comply with current Good Manufacturing Practices (cGMP). A mouse immunogenicity study was conducted using a stable oil-in-water emulsion (SE) of CS/D in combination… CONTINUE READING